We have just started using a new backup system for all of our desktops and servers and we love it. It's the easiest and safest system for backing up everything important that we have found and is actually easier than us using our own servers by a huge margin.
The backups are all done automatically and in the background and we are even notified if a backup is not performed..... Brilliant really and the price is virtually nothing for the peace of mind it gives, starting at £6.99 per computer plus 0.50p per gigabyte it suits our needs perfectly.
One of the major advantages of this system is that it backs up protected system files and files that are in use, most importantly for many people is that it is able to back up Microsoft Outlook .PST files....and it is the only backup solution that we have found that does this effectively and without error..... No mean feat considering even programs like dropbox have significant problems with this.
If you are a business with just a couple of computers and want to make sure that everything is backed up correctly and in a timely fashion this is a very good option, and if you have more infrastructure with servers and large databases this would suit you as well.